diff --git a/Include/internal/pycore_pythonrun.h b/Include/internal/pycore_pythonrun.h
index 2a544edc431e6b..36cb701673f8c9 100644
--- a/Include/internal/pycore_pythonrun.h
+++ b/Include/internal/pycore_pythonrun.h
@@ -46,6 +46,7 @@ extern PyObject * _Py_CompileStringObjectWithModule(
  * stack consumption of PyEval_EvalDefault */
 #if (defined(Py_DEBUG) \
      || defined(_Py_ADDRESS_SANITIZER) \
+     || defined(_Py_HWADDRESS_SANITIZER) \
      || defined(_Py_THREAD_SANITIZER))
 #  define _PyOS_LOG2_STACK_MARGIN 12
 #else
diff --git a/Include/pyport.h b/Include/pyport.h
index c975921beafb9e..6bfe0e05a678d6 100644
--- a/Include/pyport.h
+++ b/Include/pyport.h
@@ -561,6 +561,12 @@ extern "C" {
 #      define _Py_NO_SANITIZE_ADDRESS __attribute__((no_sanitize_address))
 #    endif
 #  endif
+#  if __has_feature(hwaddress_sanitizer)
+#    if !defined(_Py_HWADDRESS_SANITIZER)
+#      define _Py_HWADDRESS_SANITIZER
+#      define _Py_NO_SANITIZE_HWADDRESS __attribute__((no_sanitize("hwaddress")))
+#    endif
+#  endif
 #  if __has_feature(thread_sanitizer)
 #    if !defined(_Py_THREAD_SANITIZER)
 #      define _Py_THREAD_SANITIZER
@@ -572,6 +578,10 @@ extern "C" {
 #    define _Py_ADDRESS_SANITIZER
 #    define _Py_NO_SANITIZE_ADDRESS __attribute__((no_sanitize_address))
 #  endif
+#  if defined(__SANITIZE_HWADDRESS__)
+#    define _Py_HWADDRESS_SANITIZER
+#    define _Py_NO_SANITIZE_HWADDRESS __attribute__((no_sanitize("hwaddress")))
+#  endif
 #  if defined(__SANITIZE_THREAD__)
 #    define _Py_THREAD_SANITIZER
 #    define _Py_NO_SANITIZE_THREAD __attribute__((no_sanitize_thread))
diff --git a/Modules/_testinternalcapi.c b/Modules/_testinternalcapi.c
index 619f9f50574429..43d56ae970be97 100644
--- a/Modules/_testinternalcapi.c
+++ b/Modules/_testinternalcapi.c
@@ -1863,7 +1863,8 @@ static PyObject *
 check_pyobject_freed_is_freed(PyObject *self, PyObject *Py_UNUSED(args))
 {
     /* ASan or TSan would report an use-after-free error */
-#if defined(_Py_ADDRESS_SANITIZER) || defined(_Py_THREAD_SANITIZER)
+#if defined(_Py_ADDRESS_SANITIZER) || defined(_Py_THREAD_SANITIZER) || \
+    defined(_Py_HWADDRESS_SANITIZER)
     Py_RETURN_NONE;
 #else
     PyObject *op = PyObject_CallNoArgs((PyObject *)&PyBaseObject_Type);